Publications from the Bartlett group


Most recent update: November 20, 2007


Funke, T.; Healy-Fried, M.L.; Han, H.; Alberg, D.A.; Bartlett, P.A.; Schönbrunn, E. "Differential Inhibition of Class I and Class II EPSP Synthases by Tetrahedral Reaction Intermediate Analogues" Biochemistry 2007, 46, 13344-13351.


Hutton, C.A.; Bartlett, P.A. "Preparation of Diazabicyclo[4.3.0]nonene-Based Peptidomimetics" J. Org. Chem. 2007, 72, 6865-6872.


Hammond, M.C.; Bartlett, P.A. "Synthesis of Amino Acid-Derived Cyclic Acyl Amidines for Use in β-Strand Peptidomimetics" J. Org. Chem. 2007, 72, 3104-3107.


Hammond, M.C.; Harris, B.Z.; Lim, W.A.; Bartlett, P.A. "β-Strand Peptidomimetics as Potent PDZ Domain Ligands" Chem. Biol. 2006, 13 1247-51.


Bartlett, P.A.; Entzeroth, M., editors "Exploiting Chemical Diversity for Drug Discovery", Royal Society of Chemistry Biomolecular Sciences series, 2006, 420 pages, RSC Publishing (Cambridge, UK).


Yang, Y; Nesterenko, D.; Trump, R.P.; Yamaguchi, K.; Bartlett, P.A.; Drueckhammer, D.G. "Virtual Hydrocarbon and Combinatorial Databases for Use with CAVEAT" J. Chem. Inf. Modeling, 2005, 45, 1820-1823.


Phillips, S.T.; Piersanti, G.; Bartlett, P.A. "Quantifying amino acid conformational preferences and side chain-side chain interactions in β-hairpins" Proc. Natl. Acad. Sci. USA 2005, 102, 13737-13742.


Phillips, S.T.; Blasdel, L.K.; Bartlett, P.A. "@-Tides as Reporters for Molecular Associations" J. Am. Chem. Soc. 2005, 127, 4193-4198.


Priestman, M.A.; Healy, M.L.; Becker, A.; Alberg, D.G.; Bartlett, P.A.; Lushington, G.H.; Schönbrunn, E. "The Interaction of Phosphonate Analogs of the Tetrahedral Reaction Intermediate with 5-Enolpyruvylshikimate-3-phosphate Synthase (EPSPS) in Atomic Detail" Biochemistry 2005, 44, 3241-3248.


Phillips, S.T.; Blasdel, L.K.; Bartlett, P.A. "@-Tide-Stabilized β-Hairpins" J. Org. Chem. 2005, 70, 1865-1871.


Phillips, S.T.; Piersanti, G.; Rüth, M.; Gubernator, N.; van Lengerich, B.; Bartlett, P.A. "Facile Synthesis of @-Tide β-Strand Peptidomimetics: Improved Assembly in Solution and on Solid Phase" Org. Lett. 2004, 6, 4483-4485.


An, M; Bartlett, P.A. "Enzymatic Synthesis of a Ring-Contracted Analogue of 5-Enolpyruvylshikimate-3-Phosphate" Org. Lett. 2004, 6, 4065-4067.


He, Z.; Stigers Lavoie, K.D.; Bartlett, P.A.; Toney, M.D. "Conservation of Mechanism in Three Chorismate-Utilizing Enzymes" J. Am. Chem. Soc. 2003, 126, 2378-2385.


An, M.; Maitra, U.; Neidlein, U.; Bartlett, P.A."5-Enolpyruvylshikimate-3 Phosphate Synthase: Chemical Synthesis of the Tetrahedral Intermediate and Assignment of the Stereochemical Course of the Enzymatic Reaction" J. Am. Chem. Soc. 2003, 125, 12759-12767.


Hansen, K.K.; Hansen, H.C.; Clark, R.C.; Bartlett, P.A. "Identification of Novel Macrocyclic Peptidase Inhibitors via On-bead Enzymatic Cyclization" J. Org. Chem. 2003, 68, 8459-8464.


Hansen, K.K.; Grosch, B.; Greiveldinger-Poenaru, S.; Bartlett, P.A."Synthesis and Evaluation of Macrocyclic Transition State Analog Inhibitors for α-Chymotrypsin" J. Org. Chem. 2003, 68, 8465-8470.


Lewis, J.G..; Bartlett, P.A. "Amino Acid-Derived Heterocycles as Combinatorial Library Targets: Bicyclic Aminal Lactones" J. Comb. Chem. 2003, 5, 278-284.


Trump, R.P.; Bartlett, P.A. "Amino Acid-Derived Heterocycles as Combinatorial Library Targets. Spirocyclic Ketal Lactones" J. Comb. Chem. 2003, 5, 285-291.


Spaller, M.R.; Thielemann, W.; Brennan, P.E.; Bartlett, P.A. "Combinatorial Synthetic Design. Solution and Polymer-Supported Synthesis of Heterocycles via Intramolecular Aza-Diels-Alder and Iminoalcohol Cyclizations" J. Comb. Chem. 2002, 4, 516-522.







Bartlett, P.A.; Yusuff, N.; Rico, A.C.; Lindvall, M.K. "Anti-Hydrophobic Solvent Effects: An Experimental Probe for the Hydrophobic Contribution to Enzyme Inhibitor Binding", J. Am. Chem. Soc. 2002, 124, 3853-3857.



Phillips, S.T.; Rezac, M.; Abel, U.; Kossenjans, M.; Bartlett, P.A. "'@-Tides': The 1,2-Dihydro-3(6H)-pyridinone Unit as a β-Strand Mimic", J. Am. Chem. Soc. 2002, 124, 58-66.

Bartlett, P.A.; Yusuff, N.; Pyun, H.-J.; Rico, A.C.; Meyer, J.H.; Smith, W.W.; Burger, M.T. "Design of Macrocyclic Peptidase Inhibitors: The Related Roles of Structure based Approaches and Library Chemistry", in "Medicinal Chemistry into the Millenium", Campbell, M.M., Blagbrough, I.S., Eds., Royal Society of Chemistry, Cambridge (UK), 2001.


An, M.; Toochinda, T.; Bartlett, P.A. "5-Membered Ring Analogs of Shikimic Acid", J. Org. Chem. 2001, 66, 1326-1333.


Fujinaga, M.; Cherney, M.M.; Tarasova, N.I.; Bartlett, P.A.; Hanson, J.E., James, M.N.G. "Structural study of the complex between human pepsin and a phosphorus containing transition-state analog", Acta Crystallogr., Sect. D: Biol. Crystallogr. 2000, D56, 272-279.


Stigers, K.D.; Mar-Tang, R.; Bartlett, P.A. "Synthesis of Two Potential Inhibitors of para-Aminobenzoic Acid Synthase", J. Org. Chem. 1999, 64, 8409-8410.


Bartlett, P.A.: Joyce, G.F. "Combinatorial Chemistry: The Search Continues (Editorial Overview)" Curr. Opin. Chem. Biol. 1999, 3, 253-255.


(crossed-eye stereo - click on journal link for divergent stereo)

Khan, A.R.; Parish, J.C.; Fraser, M.E.; Smith, W.W.; Bartlett, P.A.; James, M.N.G. "Lowering the Entropic Barrier for Binding Conformationally Flexible Inhibitors to Enzymes" Biochemistry 1998, 37, 16839-16845.



Meyer, J.H.; Bartlett, P.A. "Macrocyclic Inhibitors of Penicillopepsin. I. Design, Synthesis, and Evaluation of an Inhibitor Bridged Between P1 and P3", J. Am. Chem. Soc. 1998, 120, 4600-4609.

Ding, J.; Fraser, M.E.; Meyer, J.H.; Bartlett, P.A.; James, M.N.G. "Macrocyclic Inhibitors of Penicillopepsin. II. X-ray Crystallographic Analyses of Penicillopepsin Complexed with a P3-P1 Macrocyclic Peptidyl Inhibitor and with its Two Acyclic Analogs", J. Am. Chem. Soc. 1998, 120, 4610-4621.




Smith, W.W.; Bartlett, P.A. "Macrocyclic Inhibitors of Penicillopepsin. III. Design, Synthesis, and Evaluation of an Inhibitor Bridged Between P2 and P1'", J. Am. Chem. Soc. 1998, 120, 4622-4628.



Smith, L.R.; Bartlett, P.A. "Novel, Amino Acid-Derived Heterobicycles: Scaffolds for β-Turn Mimics and Targets for Combinatorial Synthesis", Molecules Online 1998, 2, 58-62.




Burger, M. T.; Bartlett, P.A. "Enzymatic, Polymer-Supported Synthesis of an Analog of the Trypsin Inhibitor A90720A: A Screening Strategy for Macrocyclic Peptidase Inhibitors", J. Am. Chem. Soc. 1997, 119, 12697-12698.



Mader, M.M.; Bartlett, P.A. "Binding Energy and Catalysis: The Implications for Transition State Analogs and Catalytic Antibodies" Chem. Rev. 1997, 97, 1281-1301.




Austin, R.E.; Maplestone, R.A.; Sefler, A.M.; Liu, K.; Hruzewicz, W.N.; Liu, C.W.; Cho, H.S.; Wemmer, D.E.; Bartlett. P.A. "A Template for Stabilization of a Peptide α-Helix: Synthesis and Evaluation of Conformational Effects by Circular Dichroism and NMR", J. Am. Chem. Soc. 1997, 119, 6471-6472.




Marx, M.A.; Grillot, A.-L.; Louer, C.T.; Beaver, K.A.; Bartlett, P.A. "Synthetic Design for Combinatorial Chemistry. Solution and Polymer-Supported Synthesis of Bicyclic Lactams by Intramolecular Cyclization of Azomethine Ylides", J. Am. Chem. Soc. 1997, 119, 6153-6167.



Spaller, M.R.; Burger, M.T., Fardis, M.; Bartlett, P.A. "Synthetic Strategies in Combinatorial Chemistry", Curr. Opin. Chem. Biol. 1997, 1, 47-53.



Tian, Z.-Q.; Brown, B.B.; Hutton, C.; Mack, D.P.; Bartlett, P.A. "Potentially Macrocyclic Peptidyl Boronic Acids as Chymotrypsin Inhibitors", J. Org. Chem. 1997, 62, 514-522.



Sefler, A.M.; Kozlowski, M.C.; Guo, T.; Bartlett, P.A. "Design, Synthesis, and Evaluation of a Depsipeptide Mimic of Tendamistat", J. Org. Chem. 1997, 62, 93-102.



Kozlowski, M.C.; Bartlett, P.A. "Formation of the 7-Oxa-1,4,10-triazatricyclo[8.2.25,12]tetradecane-2,14-dione Ring System: Misrouted Synthesis of a Peptidomimetic", J. Org. Chem. 1996, 61, 7681-7696.




Sefler, A. M.; Lauri, G.; Bartlett, P. A. "A Convenient Method for Determining Cyclic Peptide Conformation from 1D 1H-NMR Information", Int. J. Pept. Prot. Res. 1996, 48, 129-138.

Bartlett, P. A. "Design of Enzyme Inhibitors: Answering Biological Questions Through Organic Synthesis" in "Organic Synthesis, From Gnosis to Prognosis" (NATO Advanced Study Institute), Chatgilialoglu, C., and Snieckus, V., Eds., Kluwer Academic Publishers, Dordrecht. 1996 137-173).



Rich, R. H.; Bartlett, P. A. "Synthesis of (-)-2-Fluoroshikimic Acid", J. Org. Chem. 1996, 61, 3916-3919.



Bartlett, P. A.; Giangiordano, M. A. "Transition State Analogy of Phosphonic Acid Peptide Inhibitors of Pepsin", J. Org. Chem. 1996, 61, 3433-3438.




Tian, Z.-Q.; Bartlett, P. A. "Metal Coordination as a Method for Templating Peptide Conformation in Structure-Based Design", J. Am. Chem. Soc. 1996, 118, 943-949.




Ellsworth, B. A.; Tom, N. J.; Bartlett, P. A. "Synthesis and Evaluation of Inhibitors of Bacterial D-Alanyl-D-Alanine Ligases", Chemistry & Biology 1996, 3, 37-44.

Bartlett, P. A.; Otake, A. "Fluoroalkenes as Peptide Isosteres: Ground State Analog Inhibitors of Thermolysin" J. Org. Chem. 1995, 60, 3107-3111.

Bartlett, P. A.; Pyun, H.-J.; Lauri, G.; Morgan, B. P. "The Interplay Between Intuition and Computer Assistance in the Design of Enzyme Inhibitors: Macrocyclic Phosphonamidates as Inhibitors of Thermolysin" in "New Perspectives in Drug Design", Dean, P. M.; Jolles, G.; Newton, C. G.; Taylor, J. B., eds., Academic Press. 1995, 51-67.

Kozlowski, M. C.; Tom, N. J.; Seto, C. T.; Sefler, A. M.; Bartlett, P. A., "Chorismate-Utilizing Enzymes Isochorismate Synthase, Anthranilate Synthase and p-Aminobenzoate Synthase: Mechanistic Insight Through Inhibitor Design", J. Am. Chem. Soc. 1995, 117, 2128-2140.

Lauhon, C. T.; Bartlett, P. A. "Substrate Analogs as Mechanistic Probes for the Bifunctional Chorismate Synthase from Neurospora crassa", Biochemistry 1994, 33, 14100-14108.

Etzkorn, F. A.; Guo, T.; Lipton M. A.; Goldberg, S. D.; Bartlett, P. A. "Cyclic Hexapeptides and Chimeric Peptides as Mimics of Tendamistat", J. Am. Chem. Soc. 1994, 116, 10412-10425.

Seto, C. T.; Bartlett, P. A. "(Z)-9-Fluoro-EPSP is Not a Substrate for EPSP Synthase: Implications for the Enzyme Mechanism", J. Org. Chem. 1994, 59, 7130-7132.

Nestler, H. P.; Bartlett, P. A.; Still, W. C. "A General Method for Molecular Tagging of Encoded Combinatorial Chemistry Libraries" J. Org. Chem. 1994, 59, 4723-4724.

Bartlett, P. A.; McLaren, K. L.; Marx, M. A., "A Divergence Between the Enzyme-Catalyzed and Non-Catalyzed Synthesis of 3-Dehydroquinate", JJ. Org. Chem. 1994, 59, 2082-2085.

Morgan, B.P.; Bartlett, P.A.; Holland, D.R.; Matthews, B.W. "Structure-Based Design of an Inhibitor of the Zinc Peptidase Thermolysin", J. Am. Chem. Soc. 1994, 116, 3251-3260.

Lauri, G.; Bartlett, P.A., "CAVEAT: A Program to Facilitate the Design of Organic Molecules", J. Comp. Aided Mol. Design. 1994, 8, 51-66.

Rich, R. H.; Lawrence, B. M.; Bartlett, P. A., "Synthesis of 2-Chloroshikimic Acid", J. Org. Chem. 1994, 59, 693-694.

Smith, W.W.; Bartlett, P.A., "An Improved Synthesis of the Transition State Analog Inhibitor of Chorismate Mutase", J. Org. Chem. 1993, 58, 7308-7309.

Simon, R.J., Kania, R.S., Zuckerman, R.N., Huebner, V.D., Jewell, D.A., Banville, S., et al. "Peptoids: A Modular Approach to Drug Discovery", Proc. Natl. Acad. Sci., U. S. A. 1992, 89, 9367-9371.

Fraser, M.E., Strynadka, N.C.J., Bartlett, P.A., Hanson, J.E. and James, M.N.G. "Crystallographic Analysis of Transition State Mimics Bound to Penicillopepsin: Phosphorus-Containing Peptide Analogues", Biochemistry 1992, 31, 5201-5214.

Alberg, D.G., Lauhon, C.T., Nyfeler, R., Fässler, A. and Bartlett, P.A. "Inhibition of EPSP Synthase by Analogs of the Tetrahedral Intermediate and of EPSP", J. Am. Chem. Soc. 1992, 114, 3535-3546.

Bartlett, P.A., Etzkorn, F.A., Guo, T., Lauri, G., Liu, K., Lipton, M., et al. "Intuitive- and Computer-Assisted Approaches to the Design of Conformationally Restrained Peptides and Their Mimics", Chemistry at the Frontiers of Medicine (Proceedings of the Robert A. Welch Foundation Conference on Chemical Research XXXV) 1992, 45-68.

Phillips, M.A., Kaplan, A.P., Rutter, W.J. and Bartlett, P.A. "Transition State Characterization: A New Approach Combining Inhibitor Analogs and Variation in Enzyme Structure", Biochemistry 1992, 31, 959-962.

Kaplan, A.P. and Bartlett, P.A. "An Inhibitor of Carboxypeptidase A with a Ki Value in the Femtomolar Range", Biochemistry 1991, 30, 8165-8170.

Bushweller, J.H. and Bartlett, P.A. "Investigation of an Octapeptide Inhibitor of E. coli Ribonucleotide Reductase by Transferred Nuclear Overhauser Effect Spectroscopy", Biochemistry 1991, 30, 8144-8151.

Bone, R., Sampson, N.S., Bartlett, P.A. and Agard, D.A. "Crystal Structures of α-Lytic Protease Complexes with Irreversibly Bound Phosphonate Esters", Biochemistry 1991, 30, 2263-2272.

Sampson, N.S. and Bartlett, P.A. "Peptidic Phosphonylating Agents as Irreversible Inhibitors of Serine Proteases and Models of the Tetrahedral Intermediates", Biochemistry 1991, 30, 2255-2263.

Kozlowski, M.C. and Bartlett, P.A. "Synthesis of a Potential Transition State Analog Inhibitor of Isochorismate Synthase", J. Am. Chem. Soc. 1991, 113, 5897-5898.

Sampson, N.S. and Bartlett, P.A. "Attempted De Novo Design, Synthesis, and Evaluation of a Ligand for the Allosteric Site of Phosphofructokinase", J. Org. Chem. 1991, 56, 7179-7183.

Åkerfeldt, K.S. and Bartlett, P.A. "Synthesis and Evaluation of Potential Multisubstrate Analog Inhibitors of Hexokinase", J. Org. Chem. 1991,56, 7133-7144.

Morgan, B.P., Scholtz, J.M., Ballinger, M., Zipkin, I. and Bartlett, P.A. "Differential Binding Energy: A Detailed Evaluation of the Influence of Hydrogen-Bonding and Hydrophobic Groups on the Inhibition of Thermolysin by Phosphorus-Containing Inhibitors", J. Am. Chem. Soc. 1991, 113, 297-307.

Copie, V., Kolbert, A.C., Drewry, D.H., Bartlett, P.A., Oas, T.G. and Griffin, R.G. "Inhibition of Thermolysin by Phosphonamidate Transition-State Analogs: Measurement of 31P-15N Bond Lengths and Chemical Shifts in Two Enzyme-Inhibitor Complexes by Solid-State Nuclear Magnetic Resonance", Biochemistry 1990, 29, 9176-9184.

Bartlett, P.A., Hanson, J.E. and Giannousis, P.P. "Potent Inhibition of Pepsin and Penicillopepsin by Phosphorus-Containing Peptide Analogs", J. Org. Chem. 1990, 55, 6268-6274.

Bartlett, P.A., Sampson, N.S., Reich, S.H., Drewry, D.H. and Lamden, L.A. "The Interplay Between Enzyme Mechanism, Protein Structure, and the Design of Serine Protease Inhibitors", in Use of X-Ray Crystallography in the Design of Antiviral Agents, G. Laver and G. Air, Editor, Academic Press; 1989, 247-259.

Bartlett, P.A., McLaren, K.L., Alberg, D.G., Fässler, A., Nyfeler, R., Lauhon, C.T., et al. "Exploration of the Shikimic Acid Pathway: Opportunities for the Study of Enzyme Mechanisms Through the Synthesis of Intermediates and Inhibitors", in Prospects for Amino Acid Biosynthesis Inhibitors in Crop Protection andPharmaceutical Chemistry, L. G. Copping, Editor, Society of Chemical Industry; 1989, 155-170.

Bartlett, P.A., Shea, G.T., Telfer, S.J. and Waterman, S. "CAVEAT: A Program to Facilitate the Structure-Derived Design of Biologically Active Molecules", in Molecular Recognition: Chemical and Biological Problems, S. M. Roberts, Editor, Royal Society of Chemistry; 1989, 182-196.

Hanson, J.E., Kaplan, A.P. and Bartlett, P.A. "Phosphonate Analogs of Carboxypeptidase A are Potent Transition State Analog Inhibitors", Biochemistry 1989, 28, 6294-6305.

Bartlett, P.A., Mori, I. and Bose, J.A. "A Subtotal Synthesis of Methynolidevia an Electrophilic Spirocyclization", J. Org. Chem. 1989, 54, 3236-3239.

Bushweller, J.H. and Bartlett, P.A. "Sulfoxide Analogs of Dihydro- and Tetrahydroprephenate as Inhibitors of Prephenate Dehydratase", J. Org. Chem. 1989, 54, 2404-2409.

Scholtz, J.M. and Bartlett, P.A. "Synthesis and Evaluation of Inhibitors for E. coli Carbamyl Phosphate Synthetase", Bioorg. Chem. 1989, 17, 422-433.

Scholtz, J.M. and Bartlett, P.A. "A Convenient Differential Protection Strategy for Functional Group Manipulation of Aspartic and Glutamic Acids", Synthesis 1989, 542-544.

Holmes, C.P. and Bartlett, P.A. "Approaches to the Tetrahydropyran Subunit of the Polyether Nigericin", J. Org. Chem. 1989, 54, 98-108.

Alberg, D.G. and Bartlett, P.A. "Potent Inhibition of 5-Enolpyruvylshikimate-3-phosphate Synthase by a Reaction Intermediate Analog", J. Am. Chem. Soc. 1989, 111, 2337-2338.

Sampson, N.S. and Bartlett, P.A. "Synthesis of Phosphonic Acid Derivatives by Oxidative Activation of Phosphinate Esters", J. Org. Chem. 1988,53, 4500-4503.

Bartlett, P.A., Nakagawa, Y., Johnson, C.R., Reich, S. and Luis, A. "Chorismate Mutase Inhibitors: Synthesis and Evaluation of Some Potential Transition State Analogs", J. Org. Chem. 1988, 53, 3195-3210.

Jackson, D.Y., Jacobs, J.W., Sugasawara, R., Reich, S.H., Bartlett, P.A. And Schultz, P.G. "An Antibody-Catalyzed Claisen Rearrangement", J. Am. Chem. Soc. 1988, 110, 4841-4842.

Bartlett, P.A. and Satake, K. "Does Dehydroquinate Synthase Synthesize Dehydroquinate?", J. Am. Chem. Soc. 1988, 110, 1628-1630.

Bartlett, P.A. and Marlowe, C.K. "A Possible Role for Water Dissociation in the Slow Binding of Phosphorus-Containing Transition State Analog Inhibitors of Thermolysin", Biochemistry 1987, 26, 8553-8561.

Bartlett, P.A., Marlowe, C.K., Giannousis, P.P. and Hanson, J.E. "Phosphorus-Containing Peptide Analogs as Peptidase Inhibitors", in Cold Spring Harbor Symposia on Quantitative Biology, 1987, Volume LII, Cold Spring HarborLaboratory; 83-90.

Bartlett, P.A. and McLaren, K.L. "Diastereoselectivity in the Alkylation ofChiral 2-Aminomethyl-1,3,2-dioxaphosphorinane-2-oxides", Phosphorus and Sulfur 1987, 33, 1-14.

Bartlett, P.A. and Marlowe, C.K. "An Analysis of the Enzyme-Inhibitor Binding Interactions for Phosphonic Acid Transition State Analogs of Thermolysin", Phosphorus and Sulfur 1987, 30, 537-543.

Bartlett, P.A. and Marlowe, C.K. "Evaluation of the Intrinsic Binding Energy from a Hydrogen Bonding Group in an Enzyme Inhibitor", Science 1987, 235, 569-571.

Mookthiar, K.A., Marlowe, C.K., Bartlett, P.A. and Van Wart, H.E. "Phosphonamidate Inhibitors of Human Neutrophil Collagenase", Biochemistry 1987, 26, 1962-1965.

Giannousis, P.P. and Bartlett, P.A. "Phosphorus Amino Acid Analogs as Inhibitors of Leucine Aminopeptidase", J. Med. Chem. 1987, 30, 1603-1609.

Bartlett, P.A., Maitra, U. and Chouinard, P.M. "Synthesis of 'iso-EPSP' and Evaluation of Its Interaction with Chorismate Synthase", J. Am. Chem. Soc. 1986, 108, 8068-8071.

Neukom, C., Richardson, D.P., Myerson, J. and Bartlett, P.A. "A Stereocontrolled Total Synthesis of (±)-Tirandamycin A", J. Am. Chem. Soc. 1986, 108, 5559-5568.

Bartlett, P.A., Vanmaele, L.J. and Kezer, W.B. "Phosphonic Acid Lactones as Potential Analogs of D-Ala-D-Ala", Bull. Soc. Chim. France 1986, 776-780.

Bartlett, P.A. and Acher, F. "Synthesis of Phosphonamides and Phosphinamides Related to Pepstatin", Bull. Soc. Chim. France 1986, 771-775.

Bartlett, P.A. and Lamden, L.A. "Inhibition of Chymotrypsin by Phosphonate and Phosphonamidate Peptide Analogs", Bioorg. Chem. 1986, 14, 356-377.

Bartlett, P.A. and Chapuis, C. "Synthesis of Polyether-Type Tetrahydrofurans via Peroxide Cyclization", J. Org. Chem. 1986, 51, 2799-2806.

Bartlett, P.A. and Ting, P.C. "Construction of trans-Fused Polycyclic Ethers: Methodology for the Brevetoxins", J. Org. Chem. 1986, 51, 2230-2240.

Chouinard, P.M. and Bartlett, P.A. "Conversion of Shikimic Acid to 5-Enolpyruvylshikimate-3-phosphate", J. Org. Chem. 1986, 51, 75-78.

Bartlett, P.A. "Synthetic Organic Chemistry and the Shikimate Pathway: Inhibitors and Intermediates", in Recent Advances in Phytochemistry, E. C. Conn, Editor, 1986, Volume 20, New York, Plenum; 119-146.

Åkerfeldt, K. and Bartlett, P.A. "Specific Synthesis and Stereochemical Assignment of the Diastereomeric 1,2-O-Isopropylidene-3,5-O-benzylidene-α-D-glucofuranose Isomers", Carbohydr. Research 1986, 158, 137-145.

Bartlett, P.A. and Johnson, C.R. "An Inhibitor of Chorismate Mutase Resembling the Transition State Conformation", J. Am. Chem. Soc. 1985, 107, 7792-7793.

Bartlett, P.A., Holm, K.H. and Morimoto, A. "Stereocontrolled Synthesis of a Polyether Fragment", J. Org. Chem. 1985, 50, 5179-5183.

Michael, J.P., Ting, P.C. and Bartlett, P.A. "Stereocontrolled Synthesis of Tetrahydrofurans and Tetrahydropyrans using Thallium(III)-Induced Cyclizations",J. Org. Chem. 1985, 50, 2416-2423.

Bartlett, P.A. "Transition State Analogs to Probe Enzyme Mechanisms", Stud. Org. Chem. 1985, 20, 439-450.

Stark, G.R. and Bartlett, P.A. "Design and Use of Potent, Specific Enzyme Inhibitors", Pharmacol. Therap. 1984, 23, 45-78.

Bartlett, P.A. "Olefin Cyclization Processes that Form Carbon-Heteratom Bonds", in Asymmetric Synthesis, J. D. Morrison, Editor, Volume 3, New York, Academic Press, Inc.; 1984, 411-454.

Bartlett, P.A. "Olefin Cyclization Processes that Form Carbon-Carbon Bonds", in Asymmetric Synthesis, J. D. Morrison, Editor, Volume 3, New York, Academic Press, Inc.; 1984, 341-409.

Ashley, G.W. and Bartlett, P.A. "Inhibition of Escherichia coli Cytidine Deaminase by a Phosphapyrimidine Nucleoside", J. Biol. Chem. 1984, 259, 13621-13627.

Ashley, G.W. and Bartlett, P.A. "Purification and Properties of Cytidine Deaminase from Escherichia coli", J. Biol. Chem. 1984, 259, 13615-13620.

Bartlett, P.A. and McQuaid, L.A. "Total Synthesis of (±)-Methyl Shikimate and (±)-3-Phosphoshikimic Acid", J. Am. Chem. Soc. 1984, 106,7854-7860.

Bartlett, P.A., Meadows, J.D. and Ottow, E. "Enantiodivergent Syntheses of (+)- and (-)-Nonactic Acid and the Total Synthesis of Nonactin", J. Am. Chem. Soc. 1984, 106, 5304-5311.

Bartlett, P.A. and Kezer, W.B. "Phosphinic Acid Dipeptide Analogs: Potent, Slow-Binding Inhibitors of Aspartic Peptidases", J. Am. Chem. Soc. 1984, 106, 4282-4283.

Bartlett, P.A.; Marlowe, C.K.; Connolly, P.J.; Banks, K.M.; et al., "Synthesis of Frontalin, the Aggregation Pheromone of the Southern Pine Beetle", J. Chem. Ed. 1984, 61, 816-817.

Ting, P.C. and Bartlett, P.A. "Stereocontrolled Synthesis of trans-2,5-Disubstituted Tetrahydrofurans", J. Am. Chem. Soc. 1984, 106, 2668-2671.

Bartlett, P.A., Richardson, D.P. and Myerson, J. "Electrophilic Lactonization as a Tool in Acyclic Stereocontrol: Synthesis of Serricornin", Tetrahedron 1984, 40, 2317-2327.

Lamden, L.A. and Bartlett, P.A. "Aminoalkylphosphonofluoridate Derivatives: Rapid and Potentially Selective Inactivators of Serine Peptidases", Biochem.Biophys. Res. Commun. 1983, 112, 1085-1090.

Bartlett, P.A. and Marlowe, C.K. "Phosphonamidates as Transition State Analog Inhibitors of Thermolysin", Biochemistry 1983, 22, 4618-4624.

Bartlett, P.A. and Chouinard, P.M. "Stereocontrolled Synthesis of E and Z 3-Deuteriophosphoenolpyruvate", J. Org. Chem. 1983, 48, 3854-3855.

Bartlett, P.A. and Holmes, C.P. "A Highly Stereoselective Synthesis of Davanone", Tetrahedron Lett. 1983, 24, 1365-1368.

Bartlett, P.A. "Stereocontrol via Cyclization Reactions", in Current Trends in Organic Synthesis, H. Nozaki, Editor, Oxford &;New York, Pergamon Press; 1983, 181-189.

Bartlett, P.A., Johnson, W.S. and Elliott, J.E. "Asymmetric Synthesis via Acetal Templates III. On the Stereochemistry Observed in the Cyclization of Chiral Acetals of Polyolefinic Aldehydes; Formation of Optically Active HomoallylicAlcohols", J. Am. Chem. Soc. 1983, 105, 2088-2089.

Jacobsen, N.E. and Bartlett, P.A. "Cyclic Phosphonic-Carboxylic Imides and Anhydrides as Reactive Intermediates. 2. Solvolysis of N-(Hydroxy(methyl)phosphinothioyl)-L-phenylalanine Derivatives", J. Am. Chem. Soc. 1983, 105, 1619-1626.

Jacobsen, N.E. and Bartlett, P.A. "Cyclic Phosphonic-Carboxylic Imides and Anhydrides as Reactive Intermediates. 1. Rearrangement and Solvolysis of N-(Amino(methyl)phosphinyl)-L-phenylalanine Derivatives", J. Am. Chem. Soc. 1983, 105, 1613-1619.

Bartlett, P.A. and Eckstein, F. "Stereochemical Course of Polymerisation Catalyzed by Avian Myeloblastosis Virus Reverse Transcriptase", J. Biol. Chem. 1982, 257, 8879-8884.

Ashley, G.W. and Bartlett, P.A. "A Phosphorus-Containing Pyrimidine Analog as a Potent Inhibitor of Cytidine Deaminase", Biochem. Biophys. Res. Commun. 1982, 108, 1467-1474.

Bartlett, P.A., Meadows, J.D., Brown, E.G., Morimoto, A. and Jernstedt, K.K."'Carbonate Extension'. A Versatile Procedure for Functionalization of AcyclicHomoallylic Alcohols with Moderate Stereocontrol", J. Org. Chem. 1982, 47, 4013-4018.

Bartlett, P.A., Tanzella, D.J. and Barstow, J.F. "Ester-Enolate Claisen Rearrangement of Lactic Acid Derivatives", J. Org. Chem. 1982, 47, 3941-3945.

Bartlett, P.A. and Barstow, J.F. "Ester-Enolate Claisen Rearrangement of α-Amino Acid Derivatives", J. Org. Chem. 1982, 47, 3933-3941.

Bartlett, P.A. and Carruthers, N.I. "An α-Diazophosphonic Acid Monoester: Synthesis, Stability, and Unexpected Photochemical Behavior", J. Chem. Soc., Chem. Commun. 1982, 536-537.

Wall, J.S., Hainfeld, J.F., Bartlett, P.A. and Singer, S.J. "Observation ofan Undecagold Cluster Compound in the Scanning Transmission Electron Microscope", Ultramicroscopy 1982, 8, 397-402.

Bartlett, P.A., Carruthers, N.I., Winter, B.M. and Long, K.P. "α-Diazophosphonic Acids as Potential Photoaffinity Labeling Reagents: Synthesis, Stability, and Photochemistry", J. Org. Chem. 1982, 47, 1284-1291.

Bartlett, P.A. and Barstow, J.F. "Stereoselective Synthesis of 2-(2'-Cycloalkenyl)glycinates via Ester-Enolate Claisen Rearrangement", Tetrahedron Lett. 1982, 23, 623-626.

Bartlett, P.A., Tanzella, D.J. and Barstow, J.F. "Stereoselective Synthesis of the Dihydroxyisoleucine Constituent of the Amanita Mushroom Toxins", Tetrahedron Lett. 1982, 23, 619-622.

Bartlett, P.A., Spear, K.L. and Jacobsen, N.E. "A Thioamide Substrate of Carboxypeptidase A", Biochemistry 1982, 21, 1608-1611.

Voll, R.J., Koerner, T.A.W., Jr., Bartlett, P.A., Bhacca, N.S., Lankin, D.C.and Younathan, E.S. "Purification of 2,5-Anhydro-D-hexitol Bis(phosphates) and Identification of a Major 1,4,6-Tris(phosphate) Contaminant by 31P-, 13C-, and 1H-NMR Spectroscopy", Carbohydr. Research 1981, 95, 145-154.

Bartlett, P.A. and Pizzo, C.F. "Evaluation of the Claisen Rearrangement of 2-Cyclohexenols for the Stereoselective Construction of a Terpene Synthon", J.Org. Chem. 1981, 46, 3896-3900.

Rychnovsky, S.D. and Bartlett, P.A. "Stereocontrolled Synthesis of cis-2,5-Disubstituted Tetrahydrofurans; and of the cis- and trans-Linalyl Oxides", J.Am. Chem. Soc. 1981, 103, 3963-3964.

Jacobsen, N.E. and Bartlett, P.A. "A Phosphorus-Containing Dipeptide Analog as an Inhibitor of Carboxypeptidase A", J. Am. Chem. Soc. 1981, 103, 654-657.

Bartlett, P.A. and Jernstedt, K.K. "A Stereocontrolled Synthesis of the Methyl Ester of (±)-Nonactic Acid", Tetrahedron Lett. 1981, 1607-1610.

Bartlett, P.A. and Adams, J.L. "A Stereoselective Total Synthesis of the Prelog-Djerassi Lactone", J. Am. Chem. Soc. 1980, 102, 337-342.

Bartlett, P.A. "Stereocontrol in the Synthesis of Acyclic Systems: Application to Natural Product Synthesis", Tetrahedron 1980, 36, 2-72.

Bartlett, P.A. and Myerson, J. "A Highly Stereoselective Synthesis of (±)-α-Multistriatin", J. Org. Chem. 1979, 44, 1625-1627.

Bartlett, P.A. and Hahne, W.F. "Stereochemical Control of the Ynamine-Claisen Rearrangement", J. Org. Chem. 1979, 44, 882-883.

Bartlett, P.A., Hunt, J.T., Adams, J.L. and Gehret, J.-C. "Phosphorus-Containing Purines and Pyrimidines: A New Class of Transition State Analogs", Bioorganic Chem. 1978, 7, 421-436.

Hunt, J.T. and Bartlett, P.A. "Regioselective Synthesis of 5-Amino-4-imidazolecarboxylates via Isonitrile Cycloaddition", Synthesis 1978, 741-742.

Summerton, J.E. and Bartlett, P.A. "Affinity Crosslinking Agents for Nucleic Acids: Use of 6-Bromo-5,5-dimethoxyhexanohydrazide for Crosslinking Cytidine to Guanosine and Crosslinking RNA to Complementary Sequences of DNA", J. Mol. Biol. 1978, 122, 145-162.

Bartlett, P.A., Bauer, B. and Singer, S.J. "Synthesis of Water-Soluble Undecagold Cluster Compounds of Potential Importance in Electron Microscopic and other Studies of Biological Systems", J. Am. Chem. Soc. 1978, 100, 5085-5089.

Bartlett, P.A. and Green, F.R., III "Total Synthesis of Brefeldin A", J. Am. Chem. Soc. 1978, 100, 4858-4865.

Bartlett, P.A., Green, F.R., III and Rose, E.H. "The Synthesis of Acetylenes from Carboxylic Acid Derivatives via β-Ketosulfones", J. Am. Chem. Soc. 1978, 100, 4852-4858.

Bartlett, P.A. and Myerson, J. "Stereoselective Epoxidation of Acyclic Olefinic Carboxylic Acids via Iodolactonization", J. Am. Chem. Soc. 1978, 100, 3950-3952.

Bartlett, P.A. and Jernstedt, K.K. "'Phosphate Extension'. A Strategem for the Stereoselective Functionalization of Acyclic Homoallylic Alcohols", J. Am. Chem. Soc. 1977, 99, 4829-4830.

Bartlett, P.A. and Long, K.P. "A New Class of Potential Photoaffinity Labels. α-Diazophosphonic Acids: Synthesis and Stability", J. Am. Chem. Soc. 1977, 99, 1267-1268.

Bartlett, P.A., Green, F.R., III and Webb, T.R. "A Mild, Oxidative Nitro-to-Carbonyl Conversion and a New Prostaglandin Synthon", Tetrahedron Lett. 1977, 331-334.

Bartlett, P.A. "Synthesis of α-Acrylic Esters and α,β-Butenolides via β-Ketosulfoxide Alkylation", J. Am. Chem. Soc. 1976, 98, 3305-3312.



Publications pre-Berkeley

Ruoho, A., Bartlett, P.A., Dutton, A. and Singer, S.J. "A Disulfide-Bridge Bifunctional Imidoester as a Reversible Cross-Linking Reagent", Biochem. Biophys. Res. Commun. 1975, 63, 417.

Bartlett, P.A., Brauman, J.I., Johnson, W.S. and Volkmann, R.A. "Concerning the Mechanism of a Nonenzymic Biogenetic-like Olefinic Cyclization", J. Am. Chem. Soc. 1973, 95, 7502-7504.

Bartlett, P.A. and Johnson, W.S. "A Stereospecific Total Synthesis of Estrone via a Cationic Olefinic Cyclization", J. Am. Chem. Soc. 1973, 95, 7501-7502.

Wick, A.E., Bartlett, P.A. and Dolphin, D. "The Total Synthesis of Ipalbidine and Ipalbine", Helv. Chim. Acta 1971, 54, 513-522.

Bartlett, P.A. and Johnson, W.S "An Improved Reagent for the O-Alkyl Cleavage of Methyl Esters by Nucleophilic Displacement", Tetrahedron Lett. 1970, 4459-4462.



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